Basement Mac Collection

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With unlockables that come boasting titles like The Box and The Chest, The Basement Collection is pretty aptly named, really. In principle, Team Meat co-founder Edmund McMillen's latest is a collection of the Flash games he put together when he was learning his craft. In actuality, it's a chance to rummage around through his old files and crates and notepads, checking out everything from design sketches that look like op art and playable prototypes that feel a little like doodles, to a selection of actual doodles and crayon drawings he did as a kid.

It's a bit indulgent, but basements always are, right? They're where you store the stuff you can't quite bring yourself to throw away, the stuff that feels formative. It's fascinating, too. Basements always are. The past isn't a foreign country. It's all so much more intimate than that. Sometimes, the past is a basement.

For anyone wanting to cling tightly to their £2.99, it's worth stating that most of the games here remain available online for free. More than that, they - obviously - still run on Flash in the collection, and they're sometimes a little laggy with it, too. What you're getting, though, is a chance to truly own the games offline, and in a way that you can't when they're just in your browser, and you're getting a certain degree of refinement to go along with them, too. There's a hub menu that manages to be lavish and minimalist - both deftly stylish and pleasantly handicraft - and for each game there has generally been a range of careful updates: new levels and art tweaks for some, fresh soundtracks for others.

Best of all, there's all that stuff from the basement: early sketches, audio QAs, a brilliant selection of music, cutting room floor scenes from Indie Game: The Movie, playable early code, and even a voice simulator for Time Fcuk, which I doubt I will ever tire of using to scare the cats. Added up, it means that, across the package, you get to see McMillen's creative life in full. You get to spend a bit more time with a designer who loves to combine clever arcade-focused ideas with clear - yet dazzlingly overwrought - art to uncommonly atmospheric effect. Tendrils, monstrous insects, endless, waddling homunculi: McMillen is game design's eternal sixth-former, it would seem, with all of the scattered frustrations and wild flashes of brilliance that suggests. (Each game comes with a credit list, too, serving as a generous reminder that while McMillen's a real talent by himself, he's also an excellent collaborator.)

So what about the games? If you're a relative newcomer to McMillen's stuff, the original Meat Boy's probably the obvious starting point. It's not the collection at its best, however. There's no pad support, as far as I could tell - I don't think there is for any of the games - and the keyboard controls and occasional lag make it feel rather primitive compared to its famous big brother. That's because it is rather primitive compared to its famous big brother, of course, and if you're willing to stick with it, it's still a witty and demanding platformer.

Tri-achnid, meanwhile, puts you in charge of a spidery sort of creature and gives you control of each of their three limbs. It's far from being my favourite part of the collection, but in a strange way, it's the game that I suspect will really stick with players the longest. It conjures a powerfully oppressive and wearying atmosphere across the course of its short campaign, and the highest praise I can give it - and I mean that most sincerely - is that I don't like it at all.

It will be available fo $4 on Steam, running on both Mac and PC. The collection has been in development for the past three months with the help of Closure developer Tyler Glaiel, whose own game will release to Steam on September 7th.

"I actually tried to do this in 2008, on disc only," McMillen tells Polygon. "I didn't at the time know anyone with the tech knowledge to actually put the collection into a single pack so I just placed the .swf files in folders on a CD along with bonus content and had the CD physically printed. It sold out within the year and by 2009 it was in the hands of a lot of prominent producers at Nintendo, Sony and Microsoft that all reached out to me about making a console game. this is actually how the Super Meat Boy deal appeared.

"I got emails weekly about the CD, and if it was ever released digitally... I've always wanted to make a collection 'game,' and Tyler had some time between the PS3 and PC release of Closure so I asked him about it and he said it was doable."

"I'm not talented, I just did something a lot for a very long time. The collection shows most of this, it shows mistakes I made and learned from and how I've built off of what I know, and ended up creating Super meat boy and Binding of Isaac. That's not saying the games are bad... Three of the games I feel are on par with SMB and Isaac (Aether, Time Fcuk and Spewer) but the rest are a bit rough around the edges in some ways for sure."

It's one of the largest personal collections of nativity scenes in the world, containing thousands of sets from dozens of countries all over the globe, and it was all put together by one woman, Mildred Turner.

The Fifth Floor is the quietest area of Young Library, with the entire floor designated for quiet study. Find group study rooms, quiet and silent Reading Rooms, group study tables, and the beautiful Charles T. Wethington Jr. Reading Room in the Rotunda. Fifth Floor stacks include Young Library's Oversize Collection and a portion of the Government Documents collection.

The Costume Shop provides costumes for productions on and off campus. We are the stewards of an enormous collection of hats, shoes, jewelry, garments, masks, and accessories. These items are primarily used for productions during the academic year (faculty and student shows) and the Summer Language Schools, but they may also be rented or borrowed by others.

Starting every week on Monday at 8:30 a.m., theatre students can reserve space via email for the current week including the weekend. Before sending a reservation request, please check availability of MAC 232 or Sunderland basement in the calendar for MAC 232 and for Sunderland Basement.

The prerequisites to the diagnosis of TGCBM include both the awareness of such a possibility during electron microscopy, and the suspicion that the basement membrane is diffusely thickened; short of these the lesion would be overlooked and morphometry not carried out. An index of suspicion for TGCBM should be upheld in the investigation of patients with proteinuria, when light and immunofluorescent microscopies are unrevealing, similar to the quest to diagnose MCN or other distinctive lesions, and to consider the use of morphometry.13, 14 Clearly, we do not advocate renal biopsy and tedious morphometry to establish the diagnosis of early diabetes, but this series of patients was distinctive for the actual lack of biochemical evidence of diabetes when renal manifestations appeared.

As thick capillary basement membrane is described in early diabetes, and is common in long-standing diabetes, it was only logical to monitor these patients with an isolated TGCBM for clinical and biochemical features of diabetes.5, 6 Initially, however, many patients clearly did not demonstrate any supporting evidence for diabetes and a few still did not after a median follow-up of 46 months. Nonetheless, a majority of patients developed consistent abnormal blood tests in the course of follow-up, establishing the diagnosis of diabetes, and ascribing TGCBM to a prediabetic state. One may argue that the coexistence of TGCBM and diabetes is merely coincidental, but whether such an argument is legitimate or refutable, the recognition of an isolated TGCBM denotes a close and important link with early diabetes or prediabetes in most of these cases.5, 6, 16

In fact, the mechanisms involved in the development of diabetic lesions or thickening of basement membrane are poorly understood, but many processes induced by hyperglycemia have been implicated, including a deranged sorbitol pathway, excessive production of advanced glycosylation end products, and synthesis of glucoaminoglycans.2, 10 As most of our patients showed no hyperglycemia at the time of biopsy, these processes unlikely contributed to the development of TGCBM. Cusumano et al16 recently observed glomerular enlargement and thickening of basement membrane in the rhesus monkey before the appearance of clinical overt diabetes, and correlated these renal lesions with hyperinsulinemia or the prediabetic state. Abnormal intrarenal hemodynamics and glomerular hyperfiltration have also been invoked in structural changes in incipient diabetes.1, 10, 16, 17 In this series, we did not measure serum insulin, glomerular size, or glomerular hyperfiltration, thus their role in the development of TGCBM is not known. 2b1af7f3a8